| 說明 |
xvii, 364 p. : ill. (some col.) ; 25 cm. |
| Contents |
Cover -- DNA: Forensic and Legal Applications -- Contents -- Foreword -- Preface -- Acknowledgments -- 1. Biochemistry, Genetics, and Replication of DNA -- 1.1 Evolution of Identification: From Faces to Fingerprints to DNA -- 1.2 DNA and Heredity -- 1.2.1 A Look at DNA from the Outside In -- 1.2.2 DNAThe Chemistry -- 1.2.3 Unique Sequence and Repetitious DNA -- 1.3 DNA Replication -- 1.3.1 Replication in the Cell -- 1.3.2 Cloning (Gene Amplification) -- 2. Biological EvidenceScience and Criminal Investigation -- 2.1 Crime Scene InvestigationBiological Evidence -- 2.1.1 Help the Victim -- 2.1.2 Protect the Scene -- 2.1.3 Document the Scene -- 2.1.4 Search the Scene -- 2.1.5 Schematic Drawing Showing Location and Photography of Items of Evidence -- 2.1.6 Packaging and Preserving Evidence -- 2.1.7 Transport to Laboratory -- 2.1.8 Sexual Assault Evidence -- 2.1.9 Evidence Handling in the Laboratory -- 2.1.10 Report Writing -- 2.2 Serology -- 2.2.1 Blood -- 2.2.2 Semen -- 2.2.3 Saliva -- 2.2.4 Urine -- 2.2.5 Hair -- 2.3 Chain of Custody -- 3. Forensic DNA Analysis Methods -- 3.1 Associative Evidence and Polymorphism -- 3.2 Restriction Fragment-Length Polymorphism -- 3.2.1 Isolation of DNA -- 3.2.2 Quantification -- 3.2.3 Restriction Enzymes: DNA Scissors -- 3.2.4 Gel Electrophoresis -- 3.2.5 Southern Blotting -- 3.2.6 Hybridization -- 3.2.7 Autoradiography and Visualization of DNA Banding Pattern -- 3.2.8 Analysis of RFLP Results -- 3.2.9 Probe Stripping from Membrane -- 3.2.10 Match Criteria -- 3.2.11 Statistics and the Product Rule -- 3.3 Polymerase Chain Reaction -- 3.3.1 Development and Theory -- 3.3.2 Isolation of DNA -- 3.3.3 Quantification -- 3.3.4 Techniques -- 3.4 Analysis of Y-Chromosome STRs -- 3.4.1 Y-Chromosome Single-Nucleotide Polymorphism Analysis -- 3.5 Analysis of Mitochondrial DNA -- 3.5.1 The Mitochondrial Genome -- 3.5.2 Quantification -- 3.5.3 Sequencing -- 3.5.4 Interpretation of Sequence Data -- 3.5.5 Heteroplasmy -- 3.5.6 Statistics -- 3.5.7 SNP Analysis of Mitochondrial DNA -- 3.6 Problems with PCR -- 3.6.1 Contamination -- 3.6.2 Degradation -- 3.6.3 Sunlight -- 3.6.4 Inhibitors -- 3.6.5 Allelic DropoutNull Alleles -- 3.6.6 Human Error -- 3.7 Underlying Facts and Assumptions in Forensic DNA Testing -- 4. Genetics, Statistics, and Databases -- 4.1 Human Genetics, Population Genetics, and Statistics -- 4.1.1 Power of Forensic DNA Analysis: How Significant Is the Match? -- 4.1.2 Genetics and Statistics -- 4.1.3 Mendel's Laws of Genetics -- 4.1.4 Meiosis -- 4.2 Population Genetics -- 4.2.1 Hardy...Weinberg Equilibrium -- 4.2.2 Subpopulations and Substructure -- 4.3 Need for Quality Control and Quality Assurance -- 4.4 SWGDAM (Formerly Known as TWGDAM) Standards -- 4.5 DNA Advisory Board -- 4.6 Mitochondrial DNA and Y-Chromosome STR Analysis and Statistical Calculations -- 4.7 Experimental Controls -- 4.8 Validation of New DNA Methods -- 4.9 Single-Nucleotide Polymorphism Analysis -- 4.10 Database Size and Composition -- 4.11 DNA Databases --tid |
| 國際標準書號 |
9780471414780 (Cloth) |
|
0471414786 (Cloth) |
|
